2023-05-31
Tens of billions of dollars acquisition, China is about to go public | Migraine small molecules
Migraine is a common neurological disorder that causes severe pain on one or both sides of the head, including nausea, vomiting, and sensitivity to light, sounds, or smells. In practice, migraine is often treated initially with analgesics such as ibuprofen, diclofenac, and triptans, as well as antiemetics as adjunctive therapy. However, few specific drugs have been approved for the preventive treatment of migraine, so off-label drug use (OLDUs) are often used in this field, such as β blockers (commonly used to lower blood pressure), anticonvulsants (such as topiramate or sodium valproate), antidepressants (such as amitriptyline), and botulinum toxin type A. According to the Guidelines for the Prevention and Treatment of Migraine in China (2022), nonsteroidal anti-inflammatory drugs (NSAIDs) and triptans are the main acute treatment drugs for migraine in China.